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J Cell Biol. 2010 Aug 23;190(4):491-500. doi: 10.1083/jcb.201004052.

Mass spectrometry-based proteomics in cell biology.

Author information

1
Organelle Architecture and Dynamics and 2 Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. tobias.walther@yale.edu

Abstract

The global analysis of protein composition, modifications, and dynamics are important goals in cell biology. Mass spectrometry (MS)-based proteomics has matured into an attractive technology for this purpose. Particularly, high resolution MS methods have been extremely successful for quantitative analysis of cellular and organellar proteomes. Rapid advances in all areas of the proteomic workflow, including sample preparation, MS, and computational analysis, should make the technology more easily available to a broad community and turn it into a staple methodology for cell biologists.

PMID:
20733050
PMCID:
PMC2928005
DOI:
10.1083/jcb.201004052
[Indexed for MEDLINE]
Free PMC Article

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