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J Cell Biol. 2010 Aug 23;190(4):487-9. doi: 10.1083/jcb.201007096.

HDM2 ERKs PCNA.

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1
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability and is associated with cell transformation.

PMID:
20733049
PMCID:
PMC2928025
DOI:
10.1083/jcb.201007096
[Indexed for MEDLINE]
Free PMC Article
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