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BMC Biol. 2010 Aug 16;8:107. doi: 10.1186/1741-7007-8-107.

Kinesin-14: the roots of reversal.

Author information

1
Centre for Mechanochemical Cell Biology, Warwick University Medical School, Gibbet Hill, Coventry CV4 7AL, UK. rob@mechanochemistry.org

Abstract

Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.

PMID:
20731883
PMCID:
PMC2922096
DOI:
10.1186/1741-7007-8-107
[Indexed for MEDLINE]
Free PMC Article

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