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Br J Surg. 2010 Nov;97(11):1716-21. doi: 10.1002/bjs.7218.

Human papillomavirus infection and anal dysplasia in renal transplant recipients.

Author information

1
Colorectal Cancer Genetics Group, Institute for Cell and Molecular Sciences, Barts and the London School of Medicine and Dentistry, London, UK.

Abstract

BACKGROUND:

Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma. Additional risk factors for HPV-related disease have not been studied in the renal transplant population. The demographics of anal HPV and associated risk factors were investigated in this population.

METHODS:

Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital. Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease.

RESULTS:

Anal dysplasia was associated with anal oncogenic HPV infection (P < 0.001), duration of immunosuppression (P = 0.050), previous genital warts (P = 0.018) and receptive anal intercourse (P = 0.013).

CONCLUSION:

Anal dysplasia was related to immunosuppression and patient factors in this cohort.

PMID:
20730855
DOI:
10.1002/bjs.7218
[Indexed for MEDLINE]
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