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Nat Rev Mol Cell Biol. 2010 Sep;11(9):633-43. doi: 10.1038/nrm2957.

Cell adhesion: integrating cytoskeletal dynamics and cellular tension.

Author information

1
Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA. jtp@virginia.edu

Abstract

Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. For most cells in most environments, movement begins with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin cytoskeleton to the substratum, generation of traction forces that move the cell forwards and disassembly of adhesions at the cell rear. Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.

PMID:
20729930
PMCID:
PMC2992881
DOI:
10.1038/nrm2957
[Indexed for MEDLINE]
Free PMC Article

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