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Nat Mater. 2010 Sep;9(9):745-9. doi: 10.1038/nmat2815. Epub 2010 Aug 22.

Colour-barcoded magnetic microparticles for multiplexed bioassays.

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1
School of Electrical Engineering and Computer Science, Seoul National University, San 56-1, Shillim 9-dong, Gwanak-ku, Seoul 151-744, South Korea.

Abstract

Encoded particles have a demonstrated value for multiplexed high-throughput bioassays such as drug discovery and clinical diagnostics. In diverse samples, the ability to use a large number of distinct identification codes on assay particles is important to increase throughput. Proper handling schemes are also needed to readout these codes on free-floating probe microparticles. Here we create vivid, free-floating structural coloured particles with multi-axis rotational control using a colour-tunable magnetic material and a new printing method. Our colour-barcoded magnetic microparticles offer a coding capacity easily into the billions with distinct magnetic handling capabilities including active positioning for code readouts and active stirring for improved reaction kinetics in microscale environments. A DNA hybridization assay is done using the colour-barcoded magnetic microparticles to demonstrate multiplexing capabilities.

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PMID:
20729849
DOI:
10.1038/nmat2815
[Indexed for MEDLINE]

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