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Autophagy. 2010 Oct;6(7):950-1. doi: 10.4161/auto.6.7.13009. Epub 2010 Oct 14.

The Golgi as a potential membrane source for autophagy.

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1
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Abstract

In macroautophagy (hereafter autophagy), a morphological hallmark is the formation of double-membrane vesicles called autophagosomes that sequester and deliver cytoplasmic components to the lysosome/vacuole for degradation. This process begins with an initial sequestering compartment, the phagophore, which expands into the mature autophagosome. A tremendous amount of work has been carried out to elucidate the mechanism of how the autophagosome is formed. However, an important missing piece in this puzzle is where the membrane comes from. Independent lines of evidence have shown that preexisting organelles may continuously supply lipids to support autophagosome formation. In our analysis, we identified several components of the late stage secretory pathway that may redirect Golgi-derived membrane to autophagosome formation in response to starvation conditions.

PMID:
20729630
PMCID:
PMC3359472
DOI:
10.4161/auto.6.7.13009
[Indexed for MEDLINE]
Free PMC Article
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