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Aging (Albany NY). 2010 Aug;2(8):471-4.

p53, ROS and senescence in the control of aging.

Author information

1
The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK.

Abstract

In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence. The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.

PMID:
20729567
PMCID:
PMC2954038
DOI:
10.18632/aging.100189
[Indexed for MEDLINE]
Free PMC Article

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