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Clin Neurophysiol. 2011 Mar;122(3):558-566. doi: 10.1016/j.clinph.2010.07.026. Epub 2010 Aug 21.

Spatial steering of deep brain stimulation volumes using a novel lead design.

Author information

1
Philips Research, High Tech Campus 34, 5656 AE, Eindhoven, The Netherlands. Electronic address: hubert.martens@philips.com.
2
Philips Research, High Tech Campus 34, 5656 AE, Eindhoven, The Netherlands.
3
Neuronexus Technologies, 3985 Research Park Dr. Suite 100, Ann Arbor, MI 48108, USA.
4
Cleveland Clinic, Department of Neurosciences, NC30, 8900 Euclid Ave., Cleveland, OH 44195, USA; University of Minnesota, Department of Neurology, 516 Delaware Street SE, Minneapolis, MN 55455, USA.
5
Cleveland Clinic, Department of Neurosciences, NC30, 8900 Euclid Ave., Cleveland, OH 44195, USA; University of Minnesota, Department of Biomedical Engineering, 7-105 NHH, 312 Church Street SE, Minneapolis, MN 55455, USA.

Abstract

OBJECTIVE:

To investigate steering the volume of activated tissue (VTA) with deep brain stimulation (DBS) using a novel high spatial-resolution lead design.

METHODS:

We examined the effect of asymmetric current-injection across the DBS-array on the VTA. These predictions were then evaluated acutely in a non-human primate implanted with the DBS-array, using motor side-effect thresholds as the metric for estimating VTA asymmetries.

RESULTS:

Simulations show the DBS-array, with electrodes arranged together in a cylindrical configuration, can generate field distributions equivalent to commercial DBS leads, and these field distributions can be modulated using field-steering methods. Stimulation with implanted DBS-arrays showed directionally-selective muscle activation, presumably through spread of stimulation fields into portions of the corticospinal tract lying in the internal capsule.

CONCLUSIONS:

Our computational and experimental studies demonstrate that the DBS-array is capable of spatially selective stimulation. Displacing VTAs away from the lead's axis can be achieved using a single simple and intuitive control parameter.

SIGNIFICANCE:

Optimal DBS likely requires non-uniform VTAs that may differentially affect a nucleus or fiber pathway. The DBS-array allows positioning VTAs with sub-millimeter precision, which is especially relevant for those patients with DBS leads placed in sub-optimal locations. This may present clinicians with an additional degree of freedom to optimize the DBS therapy.

PMID:
20729143
DOI:
10.1016/j.clinph.2010.07.026
[Indexed for MEDLINE]

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