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Exp Gerontol. 2011 May;46(5):345-8. doi: 10.1016/j.exger.2010.08.003. Epub 2010 Aug 19.

Using Drosophila melanogaster to study the positive effects of mild stress on aging.

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Université Paul-Sabatier, Centre de Recherche sur la Cognition Animale, Toulouse cedex 9, France.


Several studies in the fly Drosophila melanogaster have shown that a mild stress can increase longevity, resistance to strong stresses (e.g., heat, fungal infection, cold) and delay behavioral aging. However, not all mild stresses have similar effects on the various studied traits. For instance, exposure to cold increases resistance to a fungal infection, but hypergravity and heat shocks do not. In addition to studies in flies and other invertebrates, it is necessary to perform experiments in mammals, to know whether mild stress could be used in therapy more thoroughly than today.

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