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Bioorg Med Chem Lett. 2010 Oct 1;20(19):5918-21. doi: 10.1016/j.bmcl.2010.07.077. Epub 2010 Jul 23.

Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols.

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1
ACADIA Pharmaceuticals AB, Medeon Science Park, Per Albin Hanssons väg 35, S-205 12 Malmö, Sweden.

Abstract

1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators, for example, the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) release in rats, consistent with its profile as a PAM of CaSRs.

PMID:
20727747
DOI:
10.1016/j.bmcl.2010.07.077
[Indexed for MEDLINE]

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