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Diagn Microbiol Infect Dis. 2010 Sep;68(1):1-6. doi: 10.1016/j.diagmicrobio.2010.04.011.

In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus.

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Department of Pharmacy Practice, University of Rhode Island, Veterans Affairs Medical Center (151), Providence, RI 02908, USA.


We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus.

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