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Mol Cancer. 2010 Aug 20;9:219. doi: 10.1186/1476-4598-9-219.

Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma.

Author information

1
Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.

Abstract

BACKGROUND:

The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC.

METHODS:

Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC.

RESULTS:

The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets.

PMID:
20727157
PMCID:
PMC2936339
DOI:
10.1186/1476-4598-9-219
[Indexed for MEDLINE]
Free PMC Article

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