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OMICS. 2010 Oct;14(5):517-23. doi: 10.1089/omi.2010.0044. Epub 2010 Aug 20.

Integrative responses to high pH stress in S. cerevisiae.

Author information

1
Departament de Bioquímica i Biologia Molecular & Institut de Biotecnologia i Biomedicina, Universitat Autónoma de Barcelona, Barcelona, Spain. Joaquin.Arino@uab.es

Abstract

The budding yeast Saccharomyces cerevisiae grows far better at acidic than at neutral or alkaline pH. Consequently, even a modest alkalinization of the medium represents a stressful situation for this yeast. In the past few years, data generated by a combination of genome-wide techniques has demonstrated that adaptive responses of S. cerevisiae to high pH stress involves extensive gene remodeling as a result of the fast activation of a number of stress-related signaling pathways, such as the Rim101, the Wsc1-Pkc1-Slt2 MAP kinase, and the calcium-activated calcineurin pathways. Alkalinization of the environment also disturbs nutrient homeostasis, as deduced from its impact on iron/copper, phosphate, and glucose uptake/utilization pathways. In this review we will examine these responses, their possible interactions, and the role that they play in tolerance to high pH stress.

PMID:
20726779
DOI:
10.1089/omi.2010.0044
[Indexed for MEDLINE]

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