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Wei Sheng Yan Jiu. 2010 Jul;39(4):528-30.

[Effects of alcohol on acute myocardial ischemia induced by pituitrin in rats].

[Article in Chinese]

Author information

1
College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.

Abstract

OBJECTIVE:

To observe the effects of alcohol intake at different levels on acute myocardial ischemia induced by pituitrin in rats.

METHODS:

Forty SD male rats were randomly divided into five groups, including model control group (pituitrin, 1U/kg), positive control group (verapamil, 1 mg/kg), 5% alcohol group (0.4 g/kg), 10% alcohol group (0.8 g/kg) and 20% alcohol group (1.6 g/kg). Myocardial ischemia model was made in rats by injecting pituitrin (1U/kg) through sublingual vein. The heart rate, incidence of arrhythmia, the changes of ST segment and T wave on electrocardiogram of rats were observed and compared.

RESULTS:

The incidence of arrhythmia, the degree of elevated ST segment and T wave amplitude induced by pituitrin were remitted obviously in the 5% alcohol group (0.4 g/kg); The heart rate was slower and the change of ST segment and T wave were not affected in the 10% alcohol group (0.8 g/kg). The heart rate was slower and the elevated ST segment and the T wave amplitude were augmented significantly in the 20% alcohol group (1.6 g/kg).

CONCLUSION:

A protective effect on acute myocardial ischemia induced by pituitrin in rats was shown in the 5% alcohol group (0.4 g/kg) and an aggravation of acute myocardial ischemia induced by pituitrin was observed in the 20% alcohol group (1.6 g/kg).

PMID:
20726254
[Indexed for MEDLINE]
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