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Tetrahedron. 2010 Jun;66(25):4428-4433.

Enantioselective syntheses of both enantiomers of cis-pyrrolidine 225H.

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Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA.


The efficient and expeditious syntheses of both enantiomers of the amphibian alkaloid cis-225H have been achieved. Utilizing a common cis-2,5-disubstituted pyrrolidine building block derived from (+)-2-tropinone, the enantioselective syntheses have established the absolute configuration of these alkaloids as (+)-(2R,5S) and (-)-(5S,2R).

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