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J Clin Aesthet Dermatol. 2010 Jul;3(7):49-53.

Overcoming the Barrier Treatment of Ichthyosis: A Combination-therapy Approach.

Author information

1
Valley Hospital Medical Center, Las Vegas, Nevada.

Abstract

Ichthyosis vulgaris is an inherited disorder of keratinization that results in asteatotic scales on extensor surfaces of the arm, legs, and trunk. A combination-therapy approach with a physiological lipid-based barrier repair topical emulsion and ammonium lactate 12% lotion applied topically was shown to be effective at four-week follow up without any untoward side effects. This combination therapy addresses the importance of caring for both the corneocytes ("bricks") and the intercellular lipid bilayer ("mortar") for optimal benefit.

PMID:
20725557
PMCID:
PMC2921759

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