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Am J Hypertens. 2011 Jan;24(1):110-3. doi: 10.1038/ajh.2010.180. Epub 2010 Aug 19.

Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats.

Author information

1
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.

Abstract

BACKGROUND:

Preeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat.

METHODS:

Mean arterial pressure (MAP), and plasma sFlt-1 and tissue ROS levels were measured in the following groups: (i) pregnant controls; (ii) sFlt-1-treated pregnant rats; (iii) Tempol-treated pregnant rats; (iv) sFlt-1- and Tempol-treated pregnant rats.

RESULTS:

MAP increased from 104 ± 2 mm Hg in pregnant control rats to 118 ± 3 mm Hg (P = 0.002) in sFlt-1-infused rats. Basal and nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated levels of tissue ROS were increased in response to excess sFlt-1 during pregnancy. Pretreatment with Tempol attenuated oxidative stress and hypertension in response to sFlt-1.

CONCLUSIONS:

ROS play an important role in mediating hypertension in response to chronic sFlt-1 excess during pregnancy.

PMID:
20725052
PMCID:
PMC3129783
DOI:
10.1038/ajh.2010.180
[Indexed for MEDLINE]
Free PMC Article

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