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Am J Sports Med. 2010 Dec;38(12):2552-7. doi: 10.1177/0363546510376714. Epub 2010 Aug 19.

Cartilage intermediate layer protein gene is associated with lumbar disc degeneration in male, but not female, collegiate athletes.

Author information

1
Nippon Sport Science University, Tokyo, Japan.

Abstract

BACKGROUND:

The authors previously identified a significant association between lumbar disc degeneration (LDDG) and cartilage intermediate layer protein (CILP) single nucleotide polymorphism (SNP) in collegiate male judokas.

HYPOTHESIS:

A significant association between LDDG and the CILP SNP is observed in Japanese collegiate athletes.

STUDY DESIGN:

Cross-sectional study; Level of evidence, 3.

METHODS:

The participants were 601 trained collegiate athletes (male, 403; female, 198) from 7 different sports. Lumbar disc degeneration was evaluated using T2-weighted magnetic resonance imaging. Genotyping of the CILP gene (1184T/C) was performed by using DNA sequencing.

RESULTS:

Among the 601 collegiate athletes, the odds ratio (OR) for the occurrence of LDDG with the CILP C allele was 1.4 (95% confidence interval [CI], 1.05-1.86). By using logistic regression analysis concomitant with the interaction term and the Wald test, the authors found that weight (OR, 1.04; 95% CI, 1.02-1.06), CILP genotype (CT: OR, 2.0; 95% CI, 1.24-3.15; CC: OR, 2.9; 95% CI, 1.09-7.74), and gender (OR, 2.1; 95% CI, 1.21-3.67) were significant risk factors for LDDG. These analyses also indicated that there was no effect of the CILP genotype on LDDG in female athletes.

CONCLUSION:

The CILP SNP 1184T/C is a risk factor for male collegiate athletes. Information regarding the CILP gene polymorphism may be important for preventing and managing lumbar disc diseases, especially in male athletes.

PMID:
20724643
DOI:
10.1177/0363546510376714
[Indexed for MEDLINE]

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