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BMC Gastroenterol. 2010 Aug 19;10:95. doi: 10.1186/1471-230X-10-95.

The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats.

Author information

1
Department of Botany, University of Fort Hare, Alice 5700, South Africa.

Abstract

BACKGROUND:

Constipation is the most common gastrointestinal complaint all over the world and it is a risk factor of colorectal cancer. In this study, the efficacy of aqueous leaf extract of Aloe ferox Mill. was studied against loperamide-induced constipation in Wistar rats.

METHODS:

Constipation was induced by oral administration of loperamide (3 mg/kg body weight) while the control rats received normal saline. The constipated rats were treated with 50, 100 and 200 mg/kg body weight/day of the extract for 7 days during which the feeding characteristics, body weight, fecal properties and gastrointestinal transit ratio were monitored.

RESULTS:

The extract improved intestinal motility, increased fecal volume and normalized body weight in the constipated rats, which are indications of laxative property of the herb with the 200 mg/kg body weight of the extract showing the best efficacy.

CONCLUSION:

The effect of the extract compares favourably well with senokot, a standard laxative drug. These findings have therefore, lent scientific credence to the folkloric use of the herb as a laxative agent by the people of the Eastern Cape of South Africa.

PMID:
20723249
PMCID:
PMC2931457
DOI:
10.1186/1471-230X-10-95
[Indexed for MEDLINE]
Free PMC Article

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