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Immunol Res. 2010 Dec;48(1-3):72-83. doi: 10.1007/s12026-010-8168-8.

HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma.

Author information

1
Department of Microbiology, Immunology & Molecular Genetics, UCLA AIDS Institute, Los Angeles, CA, USA.

Abstract

HIV infection is associated with a much higher risk for the development of non-Hodgkin lymphoma (AIDS-NHL). The principal causes of lymphomagenesis in HIV-infected individuals are thought to be the loss of immune function seen in HIV infection, which results in the loss of immunoregulation of Epstein-Barr virus-infected B cells, as well as HIV infection-associated immune dysregulation, including chronic B-cell activation. In this review, we discuss recent reports that further support the importance of these factors, and we highlight emerging evidence of different mechanisms that potentially drive lymphomagenesis in HIV-infected individuals.

PMID:
20717742
PMCID:
PMC3640300
DOI:
10.1007/s12026-010-8168-8
[Indexed for MEDLINE]
Free PMC Article

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