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Chem Commun (Camb). 2010 Sep 28;46(36):6747-9. doi: 10.1039/c0cc00830c. Epub 2010 Aug 18.

A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.

Author information

1
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.

Abstract

Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.

PMID:
20717628
PMCID:
PMC3005762
DOI:
10.1039/c0cc00830c
[Indexed for MEDLINE]
Free PMC Article

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