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Nat Rev Genet. 2010 Sep;11(9):658-62. doi: 10.1038/nrg2864.

The ethics of using transgenic non-human primates to study what makes us human.

Author information

1
Department of Psychiatry and Center for Bioethics and Humanities, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA. Marilyn.Coors@ucdenver.edu

Abstract

A flood of comparative genomic data is resulting in the identification of human lineage-specific (HLS) sequences. As apes are our closest evolutionary relatives, transgenic introduction of HLS sequences into these species has the greatest potential to produce 'humanized' phenotypes and also to illuminate the functions of these sequences. We argue that such transgenic apes would also be more likely than other species to experience harm from such research, which renders such studies ethically unacceptable in apes and justifies regulatory barriers between these species and other non-human primates for HLS transgenic research.

PMID:
20717156
PMCID:
PMC2995325
DOI:
10.1038/nrg2864
[Indexed for MEDLINE]
Free PMC Article

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