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J Biol Chem. 1991 Jul 15;266(20):12944-8.

Genetic polymorphism of rat liver gangliosides.

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Institut National de la Santé et de la Recherche Medicale, Unité 76, Paris, France.


Liver ganglioside patterns of eight rat strains were classified according to two phenotypes: SHR type, characterized by predominance of b-series gangliosides (GD1b, GT1b, GQ1b), and DA type, characterized by predominance of a-series gangliosides (GM1, GD1a). Comparison of ganglioside pattern expressed in the liver of F1 hybrids and backcross F2 hybrids indicated that SHR type is controlled by a single autosomal-dominant gene which probably determines the expression of sialytransferase 2 activity for synthesis of GD3 from GM3.

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