Format

Send to

Choose Destination
See comment in PubMed Commons below
Pathologe. 2010 Oct;31 Suppl 2:134-7. doi: 10.1007/s00292-010-1339-5.

[Multilayer analysis of signal transduction and cell cycle control in GIST. Identifying new interaction partners with differential regulation].

[Article in German]

Author information

  • 1Institut für allgemeine Pathologie und pathologische Anatomie, Universitätsklinikum Freiburg, Breisacher Str. 115a, 79106 Freiburg. florian.haller@uniklinik-freiburg.de

Abstract

To identify new interactions as well as diagnostically, prognostically and therapeutically relevant differences in the regulation of gene expression in gastrointestinal stromal tumors (GISTs), we analyzed the methylation status, mRNA expression, microRNA expression, protein expression and protein phosphorylation in parallel in identical tumor tissue samples. The data were analyzed in a multilayer approach and were correlated to each other and to clinico-pathological parameters. Differentially regulated genes were mapped to signal transduction pathways which are already known to play a major role in GISTs. A functionally orientated overview of the different data layers was constructed, which enabled new insights into gene regulation in GISTs.

PMID:
20714898
DOI:
10.1007/s00292-010-1339-5
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center