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Mol Biosyst. 2011 Jan;7(1):101-15. doi: 10.1039/c005236a. Epub 2010 Aug 12.

Towards proteomics-on-chip: the role of the surface.

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Department of Chemical and Process Engineering, ChELSI Institute, The University of Sheffield, Mappin Street, Sheffield, UK.


Miniaturisation is revolutionary to high-throughput proteomics. These technologies have gained much interest in the past decade, as they allow for sensitive parallel analysis of small amounts of biological materials. This review describes the state of the art of proteomics-on-chip, with a particular focus on the fundamental proteomics-on-chip challenges. The important role of bio-interfacial interactions and strategies to control them are presented. Various coating methodologies for on-chip protein/peptide separation are reviewed to provide an overview of the principles of protein-resistant and protein immobilisation coatings, and their effectiveness.

[Indexed for MEDLINE]

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