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Mar Drugs. 2010 Jul 19;8(7):2175-84. doi: 10.3390/md8072175.

Multiple beneficial health effects of natural alkylglycerols from shark liver oil.

Author information

1
Laboratoire de Pharmacologie Moléculaire, Université de Rennes 1, France. anne-laure.deniau@chu-rennes.fr

Abstract

Alkylglycerols (alkyl-Gro) are ether lipids abundant in the liver of some elasmobranch fish species such as ratfishes and some sharks. Shark liver oil from Centrophorus squamosus (SLO), or alkyl-Gro mix from this source, have several in vivo biological activities including stimulation of hematopoiesis and immunological defences, sperm quality improvement, or anti-tumor and anti-metastasis activities. Several mechanisms are suggested for these multiple activities, resulting from incorporation of alkyl-Gro into membrane phospholipids, and lipid signaling interactions. Natural alkyl-Gro mix from SLO contains several alkyl-Gro, varying by chain length and unsaturation. Six prominent constituents of natural alkyl-Gro mix, namely 12:0, 14:0, 16:0, 18:0, 16:1 n-7, and 18:1 n-9 alkyl-Gro, were synthesized and tested for anti-tumor and anti-metastatic activities on a model of grafted tumor in mice (3LL cells). 16:1 and 18:1 alkyl-Gro showed strong activity in reducing lung metastasis number, while saturated alkyl- Gro had weaker (16:0) or no (12:0, 14:0, 18:0) effect. Multiple compounds and mechanisms are probably involved in the multiple activities of natural alkyl-Gro.

KEYWORDS:

alkylglycerols; anti-tumor activities; ether lipids; immunostimulation; shark liver oil

PMID:
20714431
PMCID:
PMC2920550
DOI:
10.3390/md8072175
[Indexed for MEDLINE]
Free PMC Article

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