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Biophys J. 2010 Aug 9;99(4):1082-90. doi: 10.1016/j.bpj.2010.05.037.

A mechanochemical model explains interactions between cortical microtubules in plants.

Author information

1
Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada.

Abstract

Microtubules anchored to the two-dimensional cortex of plant cells collide through plus-end polymerization. Collisions can result in rapid depolymerization, directional plus-end entrainment, or crossover. These interactions are believed to give rise to cellwide self-organization of plant cortical microtubules arrays, which is required for proper cell wall growth. Although the cell-wide self-organization has been well studied, less emphasis has been placed on explaining the interactions mechanistically from the molecular scale. Here we present a model for microtubule-cortex anchoring and collision-based interactions between microtubules, based on a competition between cross-linker bonding, microtubule bending, and microtubule polymerization. Our model predicts a higher probability of entrainment at smaller collision angles and at longer unanchored lengths of plus-ends. This model addresses observed differences between collision resolutions in various cell types, including Arabidopsis cells and Tobacco cells.

PMID:
20712991
PMCID:
PMC2920726
DOI:
10.1016/j.bpj.2010.05.037
[Indexed for MEDLINE]
Free PMC Article

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