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Ann N Y Acad Sci. 2010 Aug;1202:24-30. doi: 10.1111/j.1749-6632.2010.05596.x.

Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models.

Author information

1
Division of Hematology-Oncology, Department of Pediatrics, Children's Blood Foundation Laboratories, Weill Medical College of Cornell University, New York, New York, USA.

Abstract

beta-thalassemia is a disease associated with decreased beta-globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically-relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.

PMID:
20712768
PMCID:
PMC3620601
DOI:
10.1111/j.1749-6632.2010.05596.x
[Indexed for MEDLINE]
Free PMC Article
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