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Int J Dev Biol. 2010;54(6-7):1107-15. doi: 10.1387/ijdb.093054lw.

Transcription factor interplay during Drosophila haematopoiesis.

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1
Centre de Biologie du Developpement, CNRS, Universite de Toulouse, Toulouse, France. waltzer@cict.fr

Abstract

Transcription factors play a key role in regulating blood cell fate choice and differentiation. In this review, we examine current knowledge of the function and mode of action of the transcription factors implicated in haematopoiesis in Drosophila. We particularly emphasize regulation by transcription factors and cofactors, such as GATA, FOG and RUNX, whose homologues in mammals also control blood cell formation and we discuss the cross talks between these transcriptional regulators at the different stages of haematopoietic cell fate decision.

PMID:
20711988
DOI:
10.1387/ijdb.093054lw
[Indexed for MEDLINE]
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