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Semin Cell Dev Biol. 2010 Dec;21(9):866-73. doi: 10.1016/j.semcdb.2010.08.003. Epub 2010 Aug 10.

Cytokinesis through biochemical-mechanical feedback loops.

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1
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Cytokinesis is emerging as a control system defined by interacting biochemical and mechanical modules, which form a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. Though originally defined in Dictyostelium, features of the control system are recognizable in other organisms, suggesting a universal mechanism for cytokinesis regulation and contractility.

PMID:
20709619
PMCID:
PMC2991468
DOI:
10.1016/j.semcdb.2010.08.003
[Indexed for MEDLINE]
Free PMC Article
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