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Bioorg Med Chem Lett. 2010 Sep 15;20(18):5472-6. doi: 10.1016/j.bmcl.2010.07.083. Epub 2010 Jul 25.

Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones.

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1
Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA.

Abstract

The biological activities of a family of novel, lipid-linked 13-membered-ring macro-dilactones are reported. These [13]-macro-dilactones were synthesized by diacylation of functionalized diols, followed by ring-closing metathesis under conditions we had previously reported. Antimigratory, cytostatic and cytotoxic activities of the compounds against cancer cells were evaluated. Compound 13 was the most potent in the series, while compound 10 had the broadest concentration range of subtoxic antiproliferative activity. These compounds share common structural components, namely the [13]-macro-dilactone templated by an octyl alpha-glucoside 4,6-diol.

PMID:
20709546
PMCID:
PMC2930117
DOI:
10.1016/j.bmcl.2010.07.083
[Indexed for MEDLINE]
Free PMC Article
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