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Eur J Obstet Gynecol Reprod Biol. 1991 Jul 1;40(2):105-10.

Left ventricular systolic and diastolic function in term neonates after mild perinatal asphyxia.

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Laboratory of biophysics, Mother and Child Care Institute, Sverdlovsk, U.S.S.R.


To assess possible changes in myocardial contractile function and relaxation occurring after mild perinatal asphyxia, maximal blood pressure and M-mode echocardiograms were registered simultaneously in 32 normal full-term neonates and in 22 full-term asphyxiated neonates. The slope of the end-systolic pressure-dimension relation (ESPDR) was used as a reliable index for evaluation of myocardial contractility. A nonpharmacological afterload increase was performed to calculate this relation. The following most prominent changes were observed in asphyxiated neonates: slope of ESPDR 5.9 vs 14.4 mmHg/(cm/m2); normalized peak rate of left ventricular (LV) filling 2.14 vs. 4.11 s(-1); LV isovolumic relaxation period 63 vs 36 ms. These results suggest that ESPDR and parameters of LV relaxation and filling may serve as early and sensitive signs of hypoxic myocardial dysfunction.

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