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Am J Kidney Dis. 2010 Oct;56(4):774-9. doi: 10.1053/j.ajkd.2010.04.020. Epub 2010 Aug 14.

Treating profound hyponatremia: a strategy for controlled correction.

Author information

1
Rochester General Hospital, Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. richard.sterns@rochestergeneral.org

Abstract

An alcoholic patient presented with profound hyponatremia (serum sodium concentration, 96 mEq/L) caused by the combined effects of a thiazide diuretic, serotonin reuptake inhibitor, beer potomania, and hypovolemia. A computed tomographic scan of the brain was indistinguishable from one obtained 3 weeks earlier when he was normonatremic. Concurrent administration of 3% saline solution and desmopressin controlled the rate of correction to an average of 6 mEq/L daily and resulted in full neurologic recovery without evidence of osmotic demyelination. This case illustrates the value of controlled correction of profound hyponatremia.

PMID:
20709440
DOI:
10.1053/j.ajkd.2010.04.020
[Indexed for MEDLINE]

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