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Cell Host Microbe. 2010 Aug 19;8(2):132-5. doi: 10.1016/j.chom.2010.07.011.

STAT activation during viral infection in vivo: where's the interferon?

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Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.


In this issue of Cell Host & Microbe, O'Gorman et al. (2010) identify a key role for early TLR2-mediated IL-6 production and STAT3 activation in generating protective immunity against poxviruses. These findings highlight the importance of early inflammatory cytokine production in antiviral defense and have implications for enhancing vaccination efficacy.

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