Format

Send to

Choose Destination
Vision Res. 2011 Jan 28;51(2):280-7. doi: 10.1016/j.visres.2010.08.010. Epub 2010 Aug 13.

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.

Author information

1
Faculty of Life Sciences, University of Manchester, Manchester, UK. timothy.brown@manchester.ac.uk

Abstract

Emerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction protein (Cx36(-/-)) and carrying a mutation that disrupts cone phototransduction (Gnat2(cpfl3)). Electrophysiological recordings spanning the lateral geniculate revealed rod-mediated ON and OFF visual responses in virtually every cell from all major anatomical sub-compartments of this nucleus. Hence, we demonstrate that one or more classes of RGC receive input from Cx36-independent rod pathways and drive extensive ON and OFF responses across the visual thalamus.

PMID:
20709095
PMCID:
PMC3741614
DOI:
10.1016/j.visres.2010.08.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center