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Exp Eye Res. 2011 Aug;93(2):178-86. doi: 10.1016/j.exer.2010.07.009. Epub 2010 Aug 13.

The immune response in glaucoma: a perspective on the roles of oxidative stress.

Author information

1
Department of Ophthalmology & Visual Sciences, University of Louisville, Louisville, KY, USA. gulgun.tezel@louisville.edu

Abstract

Neurodegenerative insults and glial activation during glaucomatous neurodegeneration initiate an immune response to restore tissue homeostasis and facilitate tissue cleaning and healing. However, increasing risk factors over a chronic and cumulative period may lead to a failure in the regulation of innate and adaptive immune response pathways and represent a route for conversion of the beneficial immunity into a neuroinflammatory degenerative process contributing to disease progression. Oxidative stress developing through the pathogenic cellular processes of glaucoma, along with the aging-related component of oxidative stress, likely plays a critical role in shifting the physiological equilibrium. This review aims to provide a perspective on the complex interplay of cellular events during glaucomatous neurodegeneration by proposing a unifying scheme that integrates oxidative stress-related risk factors with the altered regulation of immune response in glaucoma.

PMID:
20709058
PMCID:
PMC2998544
DOI:
10.1016/j.exer.2010.07.009
[Indexed for MEDLINE]
Free PMC Article

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