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Ageing Res Rev. 2010 Nov;9 Suppl 1:S67-78. doi: 10.1016/j.arr.2010.08.001. Epub 2010 Aug 12.

The role of genetic variants in human longevity.

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1
Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105, Taiwan.

Abstract

Human longevity is a complex phenotype with a strong genetic predisposition. Increasing evidence has revealed the genetic antecedents of human longevity. This article aims to review the data of various case/control association studies that examine the difference in genetic polymorphisms between long-lived people and younger subjects across different human populations. There are more than 100 candidate genes potentially involved in human longevity; this article particularly focuses on genes of the insulin/IGF-1 pathway, FOXO3A, FOXO1A, lipoprotein metabolism (e.g., APOE and PON1), and cell-cycle regulators (e.g., TP53 and P21). Since the confirmed genetic components for human longevity are few to date, further precise assessment of the genetic contributions is required. Gaining a better understanding of the contribution of genetics to human longevity may assist in the design of improved treatment methods for age-related diseases, delay the aging process, and, ultimately, prolong the human lifespan.

PMID:
20708717
DOI:
10.1016/j.arr.2010.08.001
[Indexed for MEDLINE]
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