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Dev Cell. 2010 Aug 17;19(2):194-206. doi: 10.1016/j.devcel.2010.07.018.

Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.

Author information

1
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

Abstract

Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.

PMID:
20708583
PMCID:
PMC5319208
DOI:
10.1016/j.devcel.2010.07.018
[Indexed for MEDLINE]
Free PMC Article

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