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Int J Gynaecol Obstet. 2010 Nov;111(2):110-4. doi: 10.1016/j.ijgo.2010.06.006. Epub 2010 Aug 12.

Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan.

Author information

1
Department of Obstetrics and Gynecology, School of Medical Science, Kanazawa University, Ishikawa, Japan. masaki-i@med.kanazawa-u.ac.jp

Abstract

OBJECTIVE:

To assess the effectiveness of including HPV testing as an adjunct to conventional cytology in cervical cancer screening.

METHODS:

Atypical epithelial cells (ATC) were classified according to the 2001 Bethesda classification system. The study ran for 6 years from May 2004 to November 2009 in conjunction with public cervical cancer screening for Kanazawa City residents. Patients with ATC (ASC-US, ASC-H, and AGC) underwent parallel testing for high-risk HPV types with the Hybrid Capture II system; HPV positive and cytology-ATC cases were recalled for colposcopic examination and biopsied if necessary. Results were compared with those obtained before HPV screening was initiated.

RESULTS:

A total of 62645 women underwent screening over the 6-year period; of these, 3622 (5.8%) were ATC positive, among whom 527 (14.5%) tested HPV-positive. These 527 women (0.8% of the screened population) were recalled for colposcopic examination. The resulting 426 biopsies were diagnosed as CIN 1 (n = 187), CIN 2 (n = 53), CIN 3 (n = 11), and invasive cervical cancer (n = 2).

CONCLUSION:

HPV testing as an adjunct to conventional cytology in cervical cancer screening seems to increase detection sensitivity with proven cost-effectiveness.

PMID:
20708184
DOI:
10.1016/j.ijgo.2010.06.006
[Indexed for MEDLINE]

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