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J Perinat Med. 2010 Nov;38(6):585-7. doi: 10.1515/JPM.2010.085. Epub 2010 Aug 13.

The role of melatonin in post-partum psychosis and depression associated with bipolar disorder.

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Clinical Research Centre/Communications, Glasgow, UK.


Recent data has highlighted the association of a bipolar disorder (BD) with an increased risk of post-partum psychosis and depression. It is suggested that genetic- and environmental-induced decrease in the levels of melatonin in BD contributes to post-partum disorders. Melatonin may also have some efficacy in the treatment of BD, especially in decreasing the side-effects associated with lithium and the neuroleptics. It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.

[Indexed for MEDLINE]

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