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Biol Chem. 2010 Oct;391(10):1131-7. doi: 10.1515/BC.2010.123.

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging.

Author information

1
Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Abstract

In the past year and a half, five studies have independently established a direct connection between the hypoxic response transcription factor, HIF-1, and aging in Caenorhabditis elegans. These studies demonstrated that HIF-1 can both promote and limit longevity via pathways that are mechanistically distinct. Here, we review the current state of knowledge regarding modulation of aging by HIF-1 and speculate on potential aspects of HIF-1 function that could be relevant for mammalian longevity and healthspan.

PMID:
20707608
PMCID:
PMC4018576
DOI:
10.1515/BC.2010.123
[Indexed for MEDLINE]
Free PMC Article

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