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Nat Rev Immunol. 2010 Sep;10(9):664-74. doi: 10.1038/nri2832. Epub 2010 Aug 13.

New insights into the development of lymphoid tissues.

Author information

1
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands. sa.vandepavert@vumc.nl

Abstract

Secondary lymphoid organs are important locations for the initiation of adaptive immune responses. They develop before birth, and their formation requires interaction between lymphotoxin-α₁ß₂-expressing lymphoid-tissue inducer cells and lymphotoxin-ß receptor-expressing stromal organizer cells. Here, we discuss new insights into the earliest phases of peripheral lymph node and Peyer's patch formation that occur before lymphotoxin-ß receptor signalling and suggest a role for the developing nervous system. In addition, we discuss the differing requirements for the postnatal formation of mucosa-associated lymphoid tissues and tertiary lymphoid structures that develop at sites of chronic inflammation.

PMID:
20706277
DOI:
10.1038/nri2832
[Indexed for MEDLINE]

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