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J Intellect Disabil Res. 2010 Oct;54(10):894-905. doi: 10.1111/j.1365-2788.2010.01315.x. Epub 2010 Aug 12.

Distinguishing features of autism in boys with fragile X syndrome.

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1
FPG Child Development Institute, University of North Carolina, Chapel Hill, NC, USA. matthew.brock@unc.edu

Abstract

BACKGROUND:

Males with fragile X syndrome and autism (FXS/autism) represent a distinct subgroup of males with FXS at risk for markedly poorer outcomes. Early identification and intervention can improve outcomes for males with autism spectrum disorder.

METHOD:

To advance the development of a specialised autism screening tool for young males with FXS that could assist in early identification, backward regression was used to identify the combination of parent-report questionnaire items that best predicted autism symptoms in a sample of 60 males with FXS, ages 4-18 years old.

RESULTS:

Both social and repetitive behaviours distinguished males with FXS/autism, with repetitive behaviours playing a more prominent role than previously documented in the literature.

CONCLUSIONS:

Healthcare workers and early interventionists may be able to interview parents about a few key behaviours to determine if young child with FXS should be formally evaluated for autism. Evidence-based practices identified for children with autism spectrum disorder can be implemented as early as possible.

[Indexed for MEDLINE]

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