Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem J. 2010 Sep 1;430(2):191-8. doi: 10.1042/BJ20100427.

Regulation of TGF-beta signalling by protein phosphatases.

Author information

1
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China.

Abstract

Tight regulation of TGF-beta (transforming growth factor-beta) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-beta superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-beta signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-beta signalling and the essential role of protein phosphatases in this process.

PMID:
20704570
PMCID:
PMC3154754
DOI:
10.1042/BJ20100427
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center