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Chem Pharm Bull (Tokyo). 1991 Mar;39(3):612-5.

On the repair of thymine and thymidine bromohydrins: a possible new model for the damage and repair of nucleic acids.

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Faculty of Pharmaceutical Sciences, Kyoto University, Japan.


Bromohydrins (2, 3, 4, and 5), oxidatively damaged products of thymine bases, were repaired on exposure to sunlight, heat, and/or some reagents to regenerate the thymine bases. A radical mechanism is proposed for the repair reaction with sunlight and heat. A hypothesis concerning the biological significance of thymidine in deoxyribonucleic acid is presented.

[Indexed for MEDLINE]

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