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Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment [Internet].


Rockville (MD): Agency for Healthcare Research and Quality (US); 2006 May.
AHRQ Comparative Effectiveness Reviews.

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Blue Cross and Blue Shield Association Technology Evaluation Center EPC, Chicago, Illinois


This review compares the efficacy and adverse effects of specific erythropoietic stimulants (i.e., epoetin [alfa or beta], darbepoetin alfa) when used to manage anemia in patients undergoing cancer therapy (i.e., chemotherapy and/or radiation). This review also addresses questions relevant to optimizing the use of erythropoietic stimulants as a general class: the outcomes of using alternative thresholds to initiate or discontinue treatment and whether there are early predictors of response to treatment.

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