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Items: 5


Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.

Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G.

Mol Biol Cell. 2010 Oct 1;21(19):3279-92. doi: 10.1091/mbc.E10-05-0470. Epub 2010 Aug 11.


Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy?

Richter SN, Frasson I, Palù G.

Curr Med Chem. 2009;16(3):267-86. Review.


Role of Nef in primate lentiviral immunopathogenesis.

Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J.

Cell Mol Life Sci. 2008 Sep;65(17):2621-36. doi: 10.1007/s00018-008-8094-2. Review.


HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, Hung CH, Thomas G.

Cell. 2002 Dec 13;111(6):853-66.


HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.

Swann SA, Williams M, Story CM, Bobbitt KR, Fleis R, Collins KL.

Virology. 2001 Apr 10;282(2):267-77.

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