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Eur Neuropsychopharmacol. 2011 Jan;21(1):71-9. doi: 10.1016/j.euroneuro.2010.07.004. Epub 2010 Aug 10.

Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.

Author information

1
Department of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. abehan@rcsi.ie

Abstract

Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.

PMID:
20702067
DOI:
10.1016/j.euroneuro.2010.07.004
[Indexed for MEDLINE]

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