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J Med Case Rep. 2010 Aug 11;4:267. doi: 10.1186/1752-1947-4-267.

Cyclosporine-A therapy-induced multiple bilateral breast and accessory axillary breast fibroadenomas: a case report.

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P,O, Box 102, Department of Surgery, Faculty of Medicine, University of Khartoum, Sudan.



Breast adenoma is common. However, in the setting of post-transplantation immune suppression it may be expressed differently.


A 35-year-old Sudanese woman, with a history of renal transplantation two and half years prior to presentation, was on a single immune suppression therapy in the form of cyclosporine-A since the transplantation. During a regular follow-up visit, she was noticed to have gingival hypertrophy and bilateral breast and axillary swellings. She underwent successful surgical resection of the bilateral fibroadenomas.


Cyclosporine-A therapy post renal transplantation is associated with an increased incidence of benign breast changes as fibroadenoma. Regular follow-up and appropriate selection of immunosuppressant therapy are essential in the post transplantation management of these patients.

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